THE ZOU LAB
Together We Create Miracle
Publications
Apr 17, 2023
Liu, M.; Luo, Y.; Yan, J.; Xiong, X.; Xing, X.;* Kim, J. S.*; Zou, T.*, Photoactivation of Boronic Acid-Prodrugs via a Phenyl Radical Mechanism: Iridium(III) Anticancer Complex as an Example. J. Am. Chem. Soc., Accepted
Apr 10, 2023
Jiang, J.#; Xiong, X.#; Zou, T.* Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications. Acc. Chem. Res. Accepted, doi: 10.1021/acs.accounts.3c00037
Oct 28, 2022
Xiong, X.#; Wang, Y.#; Zou, T.* Towards Understanding the Molecular Mechanisms of Immunogenic Cell Death. ChemBioChem 2023, 24, e202200621. (ChemBioTalents special collection)
Sep 16, 2022
Luo, Y.; Cao, B.; Zhong, M.; Liu, M.; Xiong, X.; Zou, T.* Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for Robust Cancer Therapy. Angew. Chem. Int. Ed. 2022, 61, e202212689.
May 20, 2022
Xiong, X.†; Huang, K.-B.†; Wang, Y.†; Cao, B.; Luo, Y.; Chen, H.; Yang, Y.; Long, Y.; Liu, M.; Chan, A. S. C.; Liang, H.*; Zou, T.*, Target Profiling of an Iridium(III)-based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP. J. Am. Chem. Soc., 2022, 144, 10407-10416
Feb 14, 2022
Jiang, J.†; Cao, B.†; Chen, Y.†; Luo, H.; Xue, J.; Xiong, X.; Zou, T.*, Alkylgold(III) Complexes Undergo Unprecedented Photo-Induced β-Hydride Elimination and Reduction for Targeted Cancer Therapy. Angew. Chem. Int. Ed. 2022, 61, e202201103.
November 24, 2021
Xiong, X.; Liu, L.-Y.; Mao, Z.-W.*; Zou, T.*, Approaches towards understanding the mechanism-of-action of metallodrugs. Coord. Chem. Rev. 2022, 453, 214311.
April 28, 2021
Sheng, Y.#; Cao, B.#; Ou, M.; Wang, Y.; Yuan, S.; Zhang, N.; Zou, T.*; Liu, Y.*, Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure. Chem. Commun. 2021, doi: 10.1039/D1CC01767E.
January 25, 2025
Li, Z.; Huang, B.*; Wang, Y.; Yuan, W.; Wu, Y.; Yu, R.; Xing, G.*; Zou, T.*; Tao, Y.*, Design, synthesis and application in biological imaging of a novel red fluorescent dye based on a rhodanine derivative. RSC Adv. 2021, 11, 160-163.
November 5, 2020
Long, Y.#; Cao, B.#; Xiong, X.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems. Angew. Chem. Int. Ed. 2021, doi: 10.1002/anie.202013366.
August 26, 2020
Teng, T.; Li, K.*; Cheng, G.; Wang, Y.; Wang, J.; Li, J.; Zhou, C.; Liu, H.; Zou, T.; Xiong, J.; Wu, C.; Zhang, H.-X.; Che, C.-M.; Yang, C.*, Lighting Silver(I) Complexes for Solution-Processed Organic Light-Emitting Diodes and Biological Applications via Thermally Activated Delayed Fluorescence. Inorg. Chem. 2020, 59, 12122-12131.
March 25, 2020
Luo, H.; Cao, B.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Cyclometalated Gold(III)-Hydride Complexes Exhibit Visible Light-Induced Thiol Reactivity and Act as Potent Photo-Activated Anti-Cancer Agents. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie.202000528.
September 23, 2019
Huang, K.-B.#; Wang, F.-Y.#; Feng, H.-W.; Luo, H.; Long, Y.; Zou, T.*; Chan, A. S. C.; Liu, R.; Zou, H.; Chen, Z.-F.*; Liu, Y.-C.; Liu, Y.-N.; Liang, H.*, An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo. Chem. Commun. 2019, 55 (87), 13066-13069.
Papers published before 2018
Zou, T.;# Lok, C.-N.,# Wan, P.-K., Zhang, Z.-F., Fung, S.-K., Che, C.-M.* Anticancer Metal N-Neterocyclic carbene complexes of gold, platinum and palladium, Curr. Opin. Chem. Biol., 2018, 43, 30-36.
Fung, S. K.;# Zou, T.;# Cao, B.; Lee, P.-Y.; Fung, Y. M. E.; Hu, D.; Lok, C.-N.; Che, C.-M.*, Cyclometallated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets, Angew. Chem. Int. Ed. 2017, 56, 3892-3896. (Very Important Paper).
Fung, S. K.;# Zou, T.;# Cao, B.; Chen, T.; To, W.-P.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA, Nat. Commun. 2016, 7, 10655..
Zou, T.#; Zhang, J.-J.#; Cao, B.; Tong, K.-C.; Lok, C.-N.; Che, C.-M.* Deubiquitinases as Anticancer Targets of Gold Complexes, Isr. J. Chem. 2016, 2016, 56, 825-833.
Zou, T.* Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents; Springer Theses, Springer, 2016.
Yang, C; Mehmood, F; Lam, T L; Chan, S L-F; Wu, Y; Yeung, C-S; Guan, X; Li, K; Chung, C Y-S; Zhou, C; Zou, T; Che, C.-M.*, "Stable luminescent iridium(III) complexes with bis(N-heterocyclic carbene) ligands: photo-stability, excited state properties, visible-light-driven radical cyclization and CO2 reduction, and cellular imaging", Chem. Sci., 2016. 7, 3123-3136.
Andermark, V.; Göke, K.; Kokoschka, M.; Abu el Maaty, M. A.; Lum, C. T.; Zou, T.; Sun, R. W.-Y.; Aguiló, E.; Oehninger, L.; Rodríguez, L.; Bunjes, H.; Wölfl, S.; Che, C.-M.; Ott, Ingo*. Alkynyl gold(I) phosphane complexes: evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex. J. Inorg. Biochem. 2016, 160, 140–148
Zou, T.; Lum, C. T.; Lok, C.-N.; Zhang, J.-J.; Che, C.-M.*, Chemical biology of anticancer gold(III) and gold(I) complexes. Chem. Soc. Rev. 2015, 44, 8786-8801 (Outside Front Cover).
Tsai, J. L.-L.;# Zou, T.;# Liu, J.; Chen, T.; Chan, A. O.-Y.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions. Chem. Sci. 2015, 6, 3823-3830.
Zou, T., Sadler, P. J.* Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discov. Today Technol. 2015, 16, 7-15.
Zou, T., Hung, F.-F., Yang, C., Che, C.-M.* Strongly Phosphorescent Transition-Metal Complexes with N-Heterocyclic Carbene Ligands as Cellular Probes. In: Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents Strucure and Bonding. Vol. 165 (Ed.: Lo, K. K.-W.). Springer Berlin Heidelberg, 2015, pp. 181-203.
Li, K.; Zou, T.; Chen, Y.; Guan, X.; Che, C.-M. Pincer-Type Platinum(II) Complexes Containing N-Heterocyclic Carbene (NHC) Ligand: Structures, Photophysical and Anion-Binding Properties, and Anticancer Activities. Chem. Eur. J. 2015, 21, 7441–7453.
Zou, T.; Lum, C. T.; Lok, C.-N.; To, W.-P.; Low, K.-H.; Che, C.-M., A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo. Angew. Chem. Int. Ed. 2014, 53, 5810-5814.
Zou, T.;# Liu, J.;# Lum, C. T.; Ma, C.; Chan, R. C.-T.; Lok, C.-N.; Kwok, W.-M.; Che, C.-M., Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double Stranded DNA and RNA: Differential Emissions and Anticancer Activities. Angew. Chem. Int. Ed. 2014, 53, 10119-10123.
Lok, C.-N.;# Zou, T.;# Zhang, J.-J.; Lin, I. W.-S.; Che, C.-M., Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles. Adv. Mater. 2014, 26, 5550-5557.
He, L.; Chen, T.*; You, Y.; Hu, H.; Zheng, W.; Kwong, W.-L.; Zou, T.; Che, C.-M.*, "A Cancer-Targeted Nanosystem for Delivery of Gold(III) Complexes: Enhanced Selectivity and Apoptosis-Inducing Efficacy of a Gold(III) Porphyrin Complex", Angew. Chem. Int. Ed., 2014, 53, 12532-12536.
Lum, C. T.; Wai-Yin Sun, R.; Zou, T.; Che, C.-M.*, Gold(III) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene. Chem. Sci. 2014, 5, 1579-1584.
Shiu, H.-Y.; Chong, H.-C.; Leung, Y.-C.; Zou, T.; Che, C.-M.*, Phosphorescent proteins for bio-imaging and site selective bio-conjugation of peptides and proteins with luminescent cyclometalated iridium(III) complexes. Chem. Commun. 2014, 50, 4375-4378.
Lum, C. T., Zou, T., Sun, R. W. Y., Che, C.-M.* A novel platinum-carbene compound inhibits growth of lung and nasopharyngeal carcinoma xenografts in mice and downregulates proto-oncogenes. J. Thorac. Oncol. 2014, 9, S204-S205.
Zou, T.; Lum, C. T.; Chui, S. S.-Y.; Che, C.-M.*, Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents. Angew. Chem. Int. Ed. 2013, 52, 2930-2933 (Very Important Paper).
Zou, T.; Lok, C.-N.; Fung, Y. M. E.; Che, C.-M.*, Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity. Chem. Commun. 2013, 49, 5423-5425.
To, W.-P.; Zou, T.; Sun, R. W.-Y.; Che, C.-M.*, Light-induced catalytic and cytotoxic properties of phosphorescent transition metal compounds with a d8 electronic configuration. Philos. Trans. R. Soc., A 2013, 371, 20120126.
Sun, R. W.-Y.; Lok, C.-N.; Fong, T. T.-H.; Li, C. K.-L.; Yang, Z. F.; Zou, T.; Siu, A. F.-M.; Che, C.-M.*, A dinuclear cyclometalated gold(III)-phosphine complex targeting thioredoxin reductase inhibits hepatocellular carcinoma in vivo. Chem. Sci. 2013, 4, 1979-1988.
Tao, Y.; Wang, Q.; Yang, C.; Zhang, Z.; Zou, T.; Qin, J.; Ma, D., "A Simple Carbazole/Oxadiazole Hybrid Molecule: An Excellent Bipolar Host for Green and Red Phosphorescent OLEDs", Angew. Chem. Int. Ed., 2008, 47, 8104-8107.
Tao, Y.; Wang, Q.; Yang, C.; Zhang, K.; Wang, Q.; Zou, T.; Qin, J; Ma, D, "Solution-processable highly efficient yellow- and red-emitting phosphorescent organic light emitting devices from a small molecule bipolar host and iridium complexes", J. Mater. Chem., 2008, 18, 4091-4096.
# equal contribution * corresponding author